Japan developed high-sensitivity detection technology for biomarkers

Japan has developed a high-sensitivity detection technology for biomarkers. The University of Tokyo recently issued a communiqué saying that its researchers have invented a new biomarker detection technology to improve the detection sensitivity of biomarkers such as cancer cells and influenza viruses to the previous level. 1 million times. This helps detect related diseases earlier. Related papers will be published in the online version of the "Chip Lab" magazine. Antibody antigen reaction refers to the specific binding reaction between the antigen and the corresponding antibody. Antigen is a specific protein produced by cancer cells and viruses in the blood. Antibody refers to the immunoglobulin that can specifically bind to the corresponding antigen . So far, when using antibody-antigen reaction for biomarker detection, the enzyme-linked immunosorbent assay method mainly used is to adsorb soluble antigen or antibody to a solid phase carrier such as polystyrene to perform qualitative and quantitative determination of the immune response. However, due to the operation in a small test tube, the concentration is diluted and the sensitivity is low. The research team led by Professor Koji University ’s Noji Hiroki uses the precision processing technology commonly used in semiconductor manufacturing to create 1 million small holes in 1 square centimeter of glass, and then let molecules produced by the antibody antigen flow through to capture these one by one. molecule. When detecting the prostate cancer index "prostate specific antigen", even if its concentration is only one part per million of the traditional detection method, it can still be detected.

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